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Antimicrobial Agents and Chemotherapy, December 2008, p. 4518-4521, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00640-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Tet 42, a Novel Tetracycline Resistance Determinant Isolated from Deep Terrestrial Subsurface Bacteria {triangledown}

Mindy G. Brown,* Elizabeth H. Mitchell, and David L. Balkwill

Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida

Received 15 May 2008/ Returned for modification 24 July 2008/ Accepted 12 September 2008

Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.

* Corresponding author. Mailing address: Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL 32306-4300. Phone: (850) 645-2933. Fax: (850) 644-5781. E-mail: mindy.brown{at}med.fsu.edu

{triangledown} Published ahead of print on 22 September 2008.

Antimicrobial Agents and Chemotherapy, December 2008, p. 4518-4521, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00640-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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