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Antimicrobial Agents and Chemotherapy, February 2008, p. 452-457, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00908-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Vancomycin-Resistant Staphylococcus aureus Isolates Associated with Inc18-Like vanA Plasmids in Michigan{triangledown}

Wenming Zhu, Nancye C. Clark, Linda K. McDougal, Jeffery Hageman, L. Clifford McDonald, and Jean B. Patel*

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia

Received 11 July 2007/ Returned for modification 11 September 2007/ Accepted 13 November 2007

Five of the seven cases of vancomycin-resistant Staphylococcus aureus (VRSA) infection identified to date have occurred in southeastern Michigan. VRSA isolates from the four most recent cases (all from Michigan) were characterized. The vanA gene was localized to a single plasmid in each VRSA isolate. The pulsed-field gel electrophoresis patterns of chromosomal DNA and the restriction profile of the plasmid demonstrated that the four isolates were unique and differed from the first three VRSA isolates. Vancomycin-resistant Enterococcus (VRE) isolates, all of which were Enterococcus faecalis, were recovered from case patients 4 to 6. Each VRE isolate transferred vancomycin resistance to E. faecalis JH2-2 by conjugation. PCRs for vanA and the Inc18-like plasmid genes traA and repR confirmed the presence of an Inc18-like vanA plasmid in all VRE isolates and transconjugants. An Inc18-like vanA plasmid was identified in the VRSA isolate from case patient 7. These findings suggest a role of Inc18-like plasmids as vanA donors.

* Corresponding author. Mailing address: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS-G08, Atlanta, GA 30333. Phone: (404) 639-0361. Fax: (404) 639-1381. E-mail: vzp4{at}cdc.gov

{triangledown} Published ahead of print on 3 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 452-457, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00908-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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