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Antimicrobial Agents and Chemotherapy, February 2008, p. 716-718, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00760-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Intranasal Granulocyte-Macrophage Colony-Stimulating Factor Reduces the Aspergillus Burden in an Immunosuppressed Murine Model of Pulmonary Aspergillosis{triangledown}

Gerardo Quezada,1 Nadezhda V. Koshkina,1 Patrick Zweidler-McKay,1 Zichao Zhou,1 Dimitrios P. Kontoyiannis,2 and Eugenie S. Kleinerman1*

The Children's Cancer Hospital, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030,1 Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 770302

Received 12 June 2007/ Returned for modification 27 August 2007/ Accepted 26 October 2007

We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-targeted immunotherapy may be complementary to antifungal agents and may improve patient responses.

* Corresponding author. Mailing address: Department of Pediatrics, 1515 Holcombe Blvd., Box 87, Houston, TX 77030. Phone: (713) 792-8110. Fax: (713) 792-0608. E-mail: ekleiner{at}mdanderson.org

{triangledown} Published ahead of print on 5 November 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 716-718, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00760-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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