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Antimicrobial Agents and Chemotherapy, February 2008, p. 719-721, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01469-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Antimycobacterial Activities of Capuramycin Analogues{triangledown}

Venkata M. Reddy,* Leo Einck, and Carol A. Nacy

Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, Maryland 20850

Received 13 November 2007/ Returned for modification 17 November 2007/ Accepted 21 November 2007

Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 µg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.

* Corresponding author. Mailing address: Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850. Phone: (301) 762-7776. Fax: (301) 762-7778. E-mail: venkatareddy{at}sequella.com

{triangledown} Published ahead of print on 10 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 719-721, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01469-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nikonenko, B. V., Reddy, V. M., Protopopova, M., Bogatcheva, E., Einck, L., Nacy, C. A. (2009). Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis. Antimicrob. Agents Chemother. 53: 3138-3139 [Abstract] [Full Text]  


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