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Antimicrobial Agents and Chemotherapy, February 2008, p. 722-724, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01136-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage{triangledown}

G. Chamilos,1 R. E. Lewis,1,2 G. Lamaris,1 T. J. Walsh,3 and D. P. Kontoyiannis1,2*

Departments of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas,1 University of Houston College of Pharmacy, Houston, Texas,2 Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland3

Received 28 August 2007/ Returned for modification 23 September 2007/ Accepted 3 November 2007

Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O2– release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus. Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-{kappa}B pathway-related genes.

* Corresponding author. Mailing address: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 745-6839. E-mail: dkontoyi{at}mdanderson.org

{triangledown} Published ahead of print on 19 November 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 722-724, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01136-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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