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Antimicrobial Agents and Chemotherapy, February 2008, p. 739-741, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00975-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Decline in Sulfadoxine-Pyrimethamine-Resistant Alleles after Change in Drug Policy in the Amazon Region of Peru{triangledown} ,{dagger}

Zhiyong Zhou,1,2 Sean M. Griffing,1,3 Alexandre Macedo de Oliveira,1 Andrea M. McCollum,1,2,3 Wilmer Marquino Quezada,4 Nancy Arrospide,4 Ananias A. Escalante,5 and Venkatachalam Udhayakumar1*

Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 Atlanta Research and Education Foundation, Decatur, Georgia,2 Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia,3 National Institute of Health, Lima, Peru,4 School of Life Sciences, Arizona State University, Tempe, Arizona5

Received 26 July 2007/ Returned for modification 31 August 2007/ Accepted 6 November 2007

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.

* Corresponding author. Mailing address: Malaria Branch, Division of Parasitic Diseases, NCZVED, CCID, Centers for Disease Control and Prevention, Mail Stop F-12, 4770 Buford Highway, Atlanta, GA 30341. Phone: (770) 488-4047. Fax: (770) 488-4454. E-mail: vxu0{at}cdc.gov

{triangledown} Published ahead of print on 19 November 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, February 2008, p. 739-741, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00975-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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