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Antimicrobial Agents and Chemotherapy, February 2008, p. 745-747, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01095-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Are All the DNA Gyrase Mutations Found in Mycobacterium leprae Clinical Strains Involved in Resistance to Fluoroquinolones?{triangledown} ,{dagger}

Stéphanie Matrat,1 Emmanuelle Cambau,2,3 Vincent Jarlier,1,4 and Alexandra Aubry1,4*

Université Pierre et Marie Curie-Paris 6, EA1541, Paris F-75013, France,1 Laboratoire de Bactériologie-Virologie-Hygiène, AP-HP, Groupe Hospitalier Albert Chenevier-Henri Mondor, Créteil F-94000, France,2 Université Paris 12, IFR10, Créteil F-94000, France,3 Service Bactériologie, AP-HP, Groupe hospitalier Pitié-Salpêtrière, Paris F-75013, France4

Received 21 August 2007/ Returned for modification 1 November 2007/ Accepted 26 November 2007

Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.

* Corresponding author. Mailing address: Faculté de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris cedex 13, France. Phone: 33 1 40 77 97 46. Fax: 33 1 45 82 75 77. E-mail: aubry{at}chups.jussieu.fr

{triangledown} Published ahead of print on 10 December 2007.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, February 2008, p. 745-747, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01095-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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