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Antimicrobial Agents and Chemotherapy, February 2008, p. 757-760, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00945-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Inhibitory Activities of 11 Antimicrobial Agents and Bactericidal Activities of Vancomycin and Daptomycin against Invasive Methicillin-Resistant Staphylococcus aureus Isolates Obtained from 1999 through 2006{triangledown}

Robert L. Holmes1* and James H. Jorgensen2

Infectious Disease Service, Brooke Army Medical Center, Fort San Houston, Texas 78234,1 Department of Pathology, University of Texas Health Science Center and University Hospital, San Antonio, Texas 782012

Received 22 July 2007/ Returned for modification 3 September 2007/ Accepted 6 November 2007

We assessed MICs and minimal bactericidal concentrations of vancomycin, daptomycin, and nine other antimicrobials against methicillin-resistant Staphylococcus aureus isolates obtained from 1999 through 2006. No vancomycin, daptomycin, or linezolid resistance was observed. Clindamycin, gentamicin, and ciprofloxacin resistance decreased significantly. No tolerance to vancomycin or daptomycin was observed, nor was MIC creep seen.

* Corresponding author. Present address: 301 Fisher St., Keesler AFB, MS 39534. Phone: (228) 376-3568. Fax: (228) 376-0145. E-mail: robert.holmes{at}keesler.af.mil

{triangledown} Published ahead of print on 26 November 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 757-760, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00945-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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