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Antimicrobial Agents and Chemotherapy, February 2008, p. 761-766, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01128-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Doripenem and Six Comparator Drugs against 423 Aerobic and Anaerobic Bacterial Isolates from Infected Diabetic Foot Wounds{triangledown}

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 C. Vreni Merriam,1 Yumi A. Warren,1 Kerin L. Tyrrell,1 and Helen T. Fernandez1

R M Alden Research Laboratory, Santa Monica, California 90404,1 UCLA School of Medicine, Los Angeles, California 900952

Received 26 August 2007/ Returned for modification 6 October 2007/ Accepted 20 November 2007

Against 182 anaerobe and 241 aerobe strains obtained from diabetic foot infections, doripenem was the most active carbapenem against Pseudomonas aeruginosa (MIC90, 2 µg/ml), more active than imipenem against Proteus mirabilis, and ertapenem was more active against Escherichia coli and Klebsiella spp. The MIC50 and MIC90 values were ≤0.125 µg/ml for methicillin-sensitive Staphylococcus aureus and all streptococci and 0.25/1 for Bacteroides fragilis.

* Corresponding author. Mailing address: R M Alden Research Laboratory, 2021 Santa Monica Blvd., 740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: ejcgmd{at}aol.com

{triangledown} Published ahead of print on 10 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 761-766, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01128-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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