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Antimicrobial Agents and Chemotherapy, February 2008, p. 767-769, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01075-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Voriconazole, Itraconazole, and Terbinafine Alone or in Combination against Pythium insidiosum Isolates from Brazil{triangledown}

Juliana S. Argenta,1 Janio M. Santurio,2* Sydney H. Alves,2 Daniela I. B. Pereira,1 Ayrton S. Cavalheiro,2 Andréia Spanamberg,1 and Laerte Ferreiro1

Programa de Pós Graduação em Ciências Veterinárias, Setor de Micologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil,1 Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil2

Received 15 August 2007/ Returned for modification 24 October 2007/ Accepted 17 November 2007

We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.

* Corresponding author. Mailing address: Campus UFSM, Prédio 20, Sala 4139, 97105-900 Santa Maria, RS, Brazil. Phone and fax: 55 55 32208906. E-mail: santurio{at}smail.ufsm.br

{triangledown} Published ahead of print on 3 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 767-769, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01075-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cavalheiro, A. S., Maboni, G., de Azevedo, M. I., Argenta, J. S., Pereira, D. I. B., Spader, T. B., Alves, S. H., Santurio, J. M. (2009). In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum. Antimicrob. Agents Chemother. 53: 2136-2138 [Abstract] [Full Text]  


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