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Antimicrobial Agents and Chemotherapy, February 2008, p. 770-773, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00957-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Tetracycline Resistance Gene tet(W) in the Pathogenic Bacterium Clostridium difficile{triangledown}

Patrizia Spigaglia, Fabrizio Barbanti, and Paola Mastrantonio*

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy

Received 25 July 2007/ Returned for modification 18 September 2007/ Accepted 21 November 2007

In this study, the tet(W) gene region of a human clinical isolate of Clostridium difficile resistant to tetracycline was characterized. This gene was a new allele showing 99% sequence identity to the gene found in the human strain Bifidobacterium longum F8, and it is not transferable by "in vitro" mating experiments.

* Corresponding author. Mailing address: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 06 49902335. Fax: 39 06 49387112. E-mail: paola.mastrantonio{at}iss.it

{triangledown} Published ahead of print on 10 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 770-773, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00957-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ammor, M. S., Florez, A. B., Alvarez-Martin, P., Margolles, A., Mayo, B. (2008). Analysis of tetracycline resistance tet(W) genes and their flanking sequences in intestinal Bifidobacterium species. J Antimicrob Chemother 62: 688-693 [Abstract] [Full Text]  


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