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Antimicrobial Agents and Chemotherapy, February 2008, p. 774-777, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00892-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum{triangledown}

Diana Barthel,1 Martin Schlitzer,2 and Gabriele Pradel1*

Research Center for Infectious Diseases, University of Würzburg, 97070 Würzburg, Germany,1 Department of Pharmaceutical Chemistry, Philipps-University Marburg, D-35032 Marburg, Germany2

Received 6 July 2007/ Returned for modification 6 August 2007/ Accepted 19 November 2007

Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.

* Corresponding author. Mailing address: Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany. Phone: 49 (0)931 312174. Fax: 49 (0)931 312578. E-mail: gabriele.pradel{at}mail.uni-wuerzburg.de

{triangledown} Published ahead of print on 3 December 2007.

Antimicrobial Agents and Chemotherapy, February 2008, p. 774-777, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.00892-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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