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Antimicrobial Agents and Chemotherapy, February 2008, p. 778-781, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01140-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Activities of Caspofungin and Micafungin, Determined Using the Method of the European Committee on Antimicrobial Susceptibility Testing, against Yeast Isolates Obtained in France in 2005-2006

E. Dannaoui,^1,2* O. Lortholary,^1,3 D. Raoux,¹ M. E. Bougnoux,⁴ G. Galeazzi,⁵ C. Lawrence,⁶ D. Moissenet,⁷ I. Poilane,⁸ D. Hoinard,¹ F. Dromer,¹ and the YEASTS Group

Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 75724 Paris Cedex 15, France,¹ Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie—Mycologie, 75015 Paris, France,² Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Necker-Enfants-Malades, Centre d'Infectiologie Necker-Pasteur, 75015 Paris, France,³ Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Necker- Enfants-Malades, Laboratoire de Microbiologie, 75015 Paris, France,⁴ AP-HP, Hôpital Louis Mourier, Unité de Parasitologie- Mycologie, 92701 Colombes Cedex, France,⁵ AP-HP, Hôpital Raymond Poincaré, Laboratoire de Microbiologie, 92380 Garches, France,⁶ AP-HP, Hôpital Armand Trousseau, Laboratoire de Bacteriologie-Virologie, 75012 Paris, France,⁷ AP-HP, Hôpital Jean Verdier, Laboratoire de Microbiologie, 93140 Bondy, France⁸

Received 29 August 2007/ Returned for modification 23 September 2007/ Accepted 21 November 2007

The in vitro activities of caspofungin and micafungin against 1,038 yeast isolates have been determined. The caspofungin and micafungin MICs were lower for Candida albicans, Candida glabrata, and Candida tropicalis than for Candida parapsilosis, Candida guilliermondii, and Candida krusei. A clear correlation was seen between the MICs for the two drugs.

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* Corresponding author. Mailing address: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 40 61 32 50. Fax: 33 1 45 68 84 20. E-mail: dannaoui{at}pasteur.fr

Published ahead of print on 10 December 2007.

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Antimicrobial Agents and Chemotherapy, February 2008, p. 778-781, Vol. 52, No. 2
0066-4804/08/$08.00+0     doi:10.1128/AAC.01140-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

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