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Antimicrobial Agents and Chemotherapy, March 2008, p. 1136-1139, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01160-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of 35 Double Combinations of Antifungal Agents against Scedosporium apiospermum and Scedosporium prolificans{triangledown}

Manuel Cuenca-Estrella,* Ana Alastruey-Izquierdo, Laura Alcazar-Fuoli, Leticia Bernal-Martinez, Alicia Gomez-Lopez, Maria J. Buitrago, Emilia Mellado, and Juan L. Rodriguez-Tudela

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, España

Received 3 September 2007/ Returned for modification 3 November 2007/ Accepted 29 December 2007

Activities of 35 combinations of antifungal agents against Scedosporium spp. were analyzed by a checkerboard microdilution design and the summation of fractional concentration index. An average indifferent effect was detected apart from combinations of azole agents and echinocandins against Scedosporium apiospermum. Antagonism was absent for all antifungal combinations against both species.

* Corresponding author. Mailing address: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda (Madrid), Spain. Phone: 34-91-8223661. Fax: 34-91-5097966. E-mail: mcuenca-estrella{at}isciii.es

{triangledown} Published ahead of print on 14 January 2008.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1136-1139, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01160-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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