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Antimicrobial Agents and Chemotherapy, March 2008, p. 1144-1146, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01542-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin{triangledown}

Jason M. Cota,1,2 Jodi L. Grabinski,1,2 Robert L. Talbert,1,2 David S. Burgess,1,2 P. David Rogers,3 Thomas D. Edlind,4 and Nathan P. Wiederhold1,2*

The University of Texas at Austin College of Pharmacy, Austin, Texas,1 The University of Texas Health Science Center at San Antonio, San Antonio, Texas,2 The University of Tennessee College of Pharmacy, Memphis, Tennessee,3 Drexel University College of Medicine, Philadelphia, Pennsylvania4

Received 29 November 2007/ Accepted 8 December 2007

Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic {Delta}slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

* Corresponding author. Mailing address: University of Texas at Austin College of Pharmacy, UTHSCSA, PERC MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-8340. Fax: (210) 567-8328. E-mail: wiederholdn{at}uthscsa.edu

{triangledown} Published ahead of print on 17 December 2007.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1144-1146, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01542-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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