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Antimicrobial Agents and Chemotherapy, March 2008, p. 1147-1149, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01387-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America{triangledown}

Roseanne A. Ressner,1 Matthew R. Moore,2 and James H. Jorgensen3*

Brooke Army Medical Center, Fort Sam Houston, Texas,1 Centers for Disease Control and Prevention, Atlanta, Georgia,2 University of Texas Health Science Center, San Antonio, Texas3

Received 26 October 2007/ Returned for modification 22 November 2007/ Accepted 26 December 2007

Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC50 of 0.25 µg/ml, a MIC90 of 0.5 µg/ml, and a range of ≤0.008 µg/ml to 1 µg/ml.

* Corresponding author. Mailing address: Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900. Phone: (210) 567-4088. Fax: (210) 567-2367. E-mail: jorgensen{at}uthscsa.edu

{triangledown} Published ahead of print on 7 January 2008.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1147-1149, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01387-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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