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Antimicrobial Agents and Chemotherapy, March 2008, p. 1150-1152, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01019-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Bobel-24 Activity against Cryptosporidium parvum in Cell Culture and in a SCID Mouse Model{triangledown}

Cristina Rueda,1 Soledad Fenoy,1 Fernando Simón,2 and Carmen del Aguila1*

Sección de Parasitología, Departamento de Bioquímica, Biología Celular y Molecular, Facultad de Farmacia, Universidad San Pablo CEU, Urbanización Montepríncipe, Ctra. Boadilla del Monte km 5,300, 28668 Madrid, Spain,1 Departamento de Parasitología, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain2

Received 2 August 2007/ Returned for modification 24 October 2007/ Accepted 16 December 2007

The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of Cryptosporidium of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (P < 0.05) in oocyst shedding were observed in animals treated with 125 mg/kg/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.

* Corresponding author. Mailing address: Facultad de Farmacia, Urbanización Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain. Phone: 34.91.372.47.21/84. Fax: 34.91.3510496. E-mail: cagupue{at}ceu.es

{triangledown} Published ahead of print on 26 December 2007.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1150-1152, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01019-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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