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Antimicrobial Agents and Chemotherapy, March 2008, p. 1153-1155, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01351-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activities of Ceftaroline and ME1036 Tested against Clinical Strains of Community-Acquired Methicillin-Resistant Staphylococcus aureus{triangledown}

Helio S. Sader,1,2* Thomas R. Fritsche,1 and Ronald N. Jones1,3

JMI Laboratories, North Liberty, Iowa,1 Universidade Federal de Sao Paulo, Sao Paulo, Brazil,2 Tufts University School of Medicine, Boston, Massachusetts3

Received 19 October 2007/ Returned for modification 1 December 2007/ Accepted 21 December 2007

Two investigational anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) β-lactams, ceftaroline (a cephalosporin) and ME1036 (a carbapenem), were subjected to susceptibility testing by reference broth microdilution methods using 152 strains of community-acquired MRSA from the United States (47 medical centers). Ceftaroline and ME1036 were 64- and >128-fold more potent than ceftriaxone, respectively. All isolates had the Panton-Valentine leukocidin genes and staphylococcal cassette chromosome mec type IV, while 67.8% of isolates displayed pulsed-field gel electrophoresis clonal type USA300-0114.

* Corresponding author. Mailing address: JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 655-3371. E-mail: helio-sader{at}jmilabs.com

{triangledown} Published ahead of print on 7 January 2008.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1153-1155, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01351-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Morrissey, I., Biek, D., Janes, R. (2009). ME1036, a novel carbapenem, with enhanced activity against clinical isolates causing bacteraemic community-acquired pneumonia. J Antimicrob Chemother 64: 209-210 [Full Text]  
  • Vidaillac, C., Leonard, S. N., Sader, H. S., Jones, R. N., Rybak, M. J. (2009). In Vitro Activity of Ceftaroline Alone and in Combination against Clinical Isolates of Resistant Gram-Negative Pathogens, Including {beta}-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 53: 2360-2366 [Abstract] [Full Text]  
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