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Antimicrobial Agents and Chemotherapy, March 2008, p. 1156-1158, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.00923-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Selection for High-Level Telithromycin Resistance in Staphylococcus aureus Yields Mutants Resulting from an rplB-to-rplV Gene Conversion-Like Event{triangledown}

Daniel R. Gentry* and David J. Holmes

Department of Microbiology, ID-CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426

Received 16 July 2007/ Returned for modification 21 October 2007/ Accepted 7 January 2008

While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is the result of an apparent gene conversion-like event.

* Corresponding author. Mailing address: UP1345, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA 19426. Phone: (610) 917-7504. Fax: (610) 917-7901. E-mail: dan.r.gentry{at}gsk.com

{triangledown} Published ahead of print on 14 January 2008.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1156-1158, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.00923-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Castellanos, M., Romero, D. (2009). The Extent of Migration of the Holliday Junction Is a Crucial Factor for Gene Conversion in Rhizobium etli. J. Bacteriol. 191: 4987-4995 [Abstract] [Full Text]  


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