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Antimicrobial Agents and Chemotherapy, March 2008, p. 1159-1161, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01101-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens{triangledown}

Stephanie J. Wallace,1 Jian Li,1 Roger L. Nation,1* Craig R. Rayner,1,{dagger} David Taylor,2 Deborah Middleton,3 Robert W. Milne,4 Kingsley Coulthard,4,5 and John D. Turnidge6

Facility for Anti-infective Drug Development and Innovation,1 Department of Pharmaceutical Biology, Victorian College of Pharmacy, Monash University, Parkville, Melbourne, Victoria 3052,2 CSIRO Australian Animal Health Laboratory, East Geelong, Victoria 3220,3 Sansom Institute, School of Pharmacy and Medical Science, University of South Australia, Adelaide, South Australia 5000,4 Department of Pharmacy,5 Division of Laboratory Medicine, Women's and Children's Hospital, North Adelaide, South Australia 5006, Australia6

Received 22 August 2007/ Returned for modification 15 October 2007/ Accepted 25 December 2007

The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.

* Corresponding author. Mailing address: Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Phone: 61 3 9903 9061. Fax: 61 3 9903 9629. E-mail: Roger.Nation{at}vcp.monash.edu.au

{triangledown} Published ahead of print on 7 January 2008.

{dagger} Present address: F. Hoffman-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1159-1161, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01101-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Plachouras, D., Karvanen, M., Friberg, L. E., Papadomichelakis, E., Antoniadou, A., Tsangaris, I., Karaiskos, I., Poulakou, G., Kontopidou, F., Armaganidis, A., Cars, O., Giamarellou, H. (2009). Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria. Antimicrob. Agents Chemother. 53: 3430-3436 [Abstract] [Full Text]  
  • Wallace, S. J., Li, J., Rayner, Craig. R., Coulthard, K., Nation, R. L. (2008). Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients. Antimicrob. Agents Chemother. 52: 3047-3051 [Abstract] [Full Text]  
  • Landman, D., Georgescu, C., Martin, D. A., Quale, J. (2008). Polymyxins Revisited. Clin. Microbiol. Rev. 21: 449-465 [Abstract] [Full Text]  


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