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Antimicrobial Agents and Chemotherapy, March 2008, p. 1171-1172, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01274-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Dectin-1 Fc Targeting of Aspergillus fumigatus Beta-Glucans Augments Innate Defense against Invasive Pulmonary Aspergillosis{triangledown}

Polly E. Mattila,1 Allison E. Metz,2 Rekha R. Rapaka,1 Lynne D. Bauer,1 and Chad Steele2*

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania,1 Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama2

Received 1 October 2007/ Returned for modification 20 November 2007/ Accepted 8 December 2007

Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.

* Corresponding author. Mailing address: Department of Medicine, School of Medicine, University of Alabama at Birmingham, 1900 University Blvd., Birmingham, AL 35294. Phone: (205) 996-9598. Fax: (205) 934-1721. E-mail: chadsteele{at}uab.edu

{triangledown} Published ahead of print on 17 December 2007.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1171-1172, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01274-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Ramaprakash, H., Ito, T., Standiford, T. J., Kunkel, S. L., Hogaboam, C. M. (2009). Toll-Like Receptor 9 Modulates Immune Responses to Aspergillus fumigatus Conidia in Immunodeficient and Allergic Mice. Infect. Immun. 77: 108-119 [Abstract] [Full Text]  


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