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Antimicrobial Agents and Chemotherapy, March 2008, p. 1176-1178, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01425-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Assessment of Serum (1->3)-β-D-Glucan Concentration as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis{triangledown}

Nathan P. Wiederhold,1,2* Laura K. Najvar,2 Ana C. Vallor,2 William R. Kirkpatrick,2 Rosie Bocanegra,2 Destiny Molina,2 Marcos Olivo,2 John R. Graybill,2 and Thomas F. Patterson2

The University of Texas at Austin College of Pharmacy, Austin, Texas,1 The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, Texas2

Received 2 November 2007/ Returned for modification 30 November 2007/ Accepted 15 December 2007

Serum (1->3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1->3)-β-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

* Corresponding author. Mailing address: UTHSCSA, PERC MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-8340. Fax: (210) 567-8328. E-mail: wiederholdn{at}uthscsa.edu

{triangledown} Published ahead of print on 26 December 2007.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1176-1178, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01425-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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