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Antimicrobial Agents and Chemotherapy, March 2008, p. 1184-1186, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01247-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil{triangledown}

David Sevillano,1 Lorenzo Aguilar,1 Luis Alou,1 María-José Giménez,1 Martha Torrico,1 Natalia González,1 Fabio Cafini,1 María-Teresa Relaño,1 Pilar Coronel,2 and José Prieto1*

Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain,1 Scientific Department, Tedec-Meiji Farma S.A., Alcalá de Henares, Madrid, Spain2

Received 24 September 2007/ Returned for modification 1 December 2007/ Accepted 16 December 2007

Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.

* Corresponding author. Mailing address: Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s/n, 28040 Madrid, Spain. Phone: 34 91 3941508. Fax: 34 91 3941511. E-mail: jprieto{at}med.ucm.es

{triangledown} Published ahead of print on 26 December 2007.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1184-1186, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01247-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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