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Antimicrobial Agents and Chemotherapy, March 2008, p. 1187-1189, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01475-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections{triangledown}

Thomas R. Fritsche,1* Paul R. Rhomberg,1 Helio S. Sader,1,2 and Ronald N. Jones1,3

JMI Laboratories, North Liberty, Iowa,1 Universidade Federal de Sao Paulo, Sao Paulo, Brazil,2 Tufts University School of Medicine, Boston, Massachusetts3

Received 14 November 2007/ Returned for modification 18 December 2007/ Accepted 28 December 2007

Omiganan, a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections, inhibited commonly occurring fungal pathogens including Candida spp. (106 isolates) at ≤256 µg/ml and molds (including 10 Aspergillus isolates) at ≤1,024 µg/ml. All fungi were inhibited by omiganan at concentrations well below the 1% (10,000 µg/ml) clinical formulation, including species with reduced susceptibility to azoles and echinocandins.

* Corresponding author. Mailing address: JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 655-3371. E-mail: thomas-fritsche{at}jmilabs.com

{triangledown} Published ahead of print on 7 January 2008.

Antimicrobial Agents and Chemotherapy, March 2008, p. 1187-1189, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01475-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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