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Antimicrobial Agents and Chemotherapy, March 2008, p. 1190-1194, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01260-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increasing Genetic Relatedness of Ciprofloxacin-Resistant Streptococcus pneumoniae Isolated in Canada from 1997 to 2005{triangledown}

Kimberly A. Nichol,1* Heather J. Adam,2 James A. Karlowsky,1,2 George G. Zhanel,2 and Daryl J. Hoban1,2

Diagnostic Services of Manitoba/Department of Clinical Microbiology, Health Sciences Centre,1 Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada2

Received 27 September 2007/ Returned for modification 15 November 2007/ Accepted 23 December 2007

The genetic relatedness of ciprofloxacin-resistant Streptococcus pneumoniae isolates collected from 1997 to 2002 (n = 82) and 2003 to 2005 (n = 123) was compared by pulsed-field gel electrophoresis (PFGE). Increased genetic homogeneity among the isolates from 2003 to 2005 (cluster analysis; P < 0.001) appeared to be due to expansion of existing clonal groups and to introduction of new PFGE types.


* Corresponding author. Mailing address: Department of Clinical Microbiology, Health Sciences Centre, MS673 - 820 Sherbrook St., Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax: (204) 787-4699. E-mail: knichol{at}hsc.mb.ca

{triangledown} Published ahead of print on 7 January 2008.


Antimicrobial Agents and Chemotherapy, March 2008, p. 1190-1194, Vol. 52, No. 3
0066-4804/08/$08.00+0     doi:10.1128/AAC.01260-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.







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