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Antimicrobial Agents and Chemotherapy, April 2008, p. 1252-1256, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01304-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Acinetobacter radioresistens as a Silent Source of Carbapenem Resistance for Acinetobacter spp.{triangledown}

Laurent Poirel,1 Samy Figueiredo,1 Vincent Cattoir,1 Alessandra Carattoli,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Université Paris XI, Le Kremlin-Bicêtre, France,1 Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy2

Received 10 October 2007/ Returned for modification 14 November 2007/ Accepted 4 January 2008

Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The blaOXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for blaOXA-23-like genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded blaOXA-23-like genes. A similar plasmid backbone was identified in several blaOXA-23-positive A. baumannii and A. radioresistens isolates, further strengthening the vectors of exchanges for these blaOXA-23-like genes. Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the blaOXA-23 gene.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, Le Kremlin-Bicêtre 94275, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 14 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1252-1256, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01304-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Boo, T. W., Crowley, B. (2009). Detection of blaOXA-58 and blaOXA-23-like genes in carbapenem-susceptible Acinetobacter clinical isolates: should we be concerned?. J Med Microbiol 58: 839-841 [Full Text]  
  • Mendes, R. E., Bell, J. M., Turnidge, J. D., Castanheira, M., Deshpande, L. M., Jones, R. N. (2009). Codetection of blaOXA-23-Like Gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: Report from the SENTRY Antimicrobial Surveillance Program. Antimicrob. Agents Chemother. 53: 843-844 [Full Text]  
  • Mendes, R. E., Bell, J. M., Turnidge, J. D., Castanheira, M., Jones, R. N. (2009). Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. in Asia-Pacific nations: report from the SENTRY Surveillance Program. J Antimicrob Chemother 63: 55-59 [Abstract] [Full Text]  
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