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Antimicrobial Agents and Chemotherapy, April 2008, p. 1500-1502, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00574-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Multilaboratory Testing of Antifungal Combinations against a Quality Control Isolate of Candida krusei{triangledown} ,{dagger}

Vishnu Chaturvedi,1* Rama Ramani,1 Mahmoud A. Ghannoum,2 Scott B. Killian,3 Nicole Holliday,3 Cindy Knapp,3 Luis Ostrosky-Zeichner,4 Shawn A. Messer,5 Michael A. Pfaller,5 Naureen J. Iqbal,6 Beth A. Arthington-Skaggs,6 Jose A. Vazquez,7 Tin Sein,8 John H. Rex,9 and Thomas J. Walsh8

Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York,1 Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio,2 TREK Diagnostic Systems, Cleveland, Ohio,3 University of Texas, Houston, Texas,4 University of Iowa, Iowa City, Iowa,5 Centers for Disease Control and Prevention, Atlanta, Georgia,6 Wayne State University, Detroit, Michigan,7 National Cancer Institute, Bethesda, Maryland,8 AstraZeneca Pharmaceuticals, Cheshire, United Kingdom9

Received 2 May 2007/ Returned for modification 12 July 2007/ Accepted 22 January 2008

Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration.

* Corresponding author. Mailing address: Mycology Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave., Albany, NY 12208. Phone: (518) 474-4177. Fax: (518) 486-7971. E-mail: vishnu{at}wadsworth.org

{triangledown} Published ahead of print on 28 January 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1500-1502, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00574-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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