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Antimicrobial Agents and Chemotherapy, April 2008, p. 1510-1512, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01529-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa{triangledown}

Todd A. Davies,* Wenchi Shang, Karen Bush, and Robert K. Flamm

Johnson and Johnson Pharmaceutical Research and Development LLC, Raritan, New Jersey

Received 27 November 2007/ Returned for modification 31 December 2007/ Accepted 22 January 2008

Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.

* Corresponding author. Mailing address: Johnson and Johnson Pharmaceutical Research and Development, LLC, Room B225, 1000 Route 202, Raritan, NJ 08869. Phone: (908) 707-3465. Fax: (908) 707-3501. E-mail: tdavies{at}prdus.jnj.com

{triangledown} Published ahead of print on 4 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1510-1512, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01529-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Koga, T., Sugihara, C., Kakuta, M., Masuda, N., Namba, E., Fukuoka, T. (2009). Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 53: 1238-1241 [Abstract] [Full Text]  


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