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Antimicrobial Agents and Chemotherapy, April 2008, p. 1513-1515, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00897-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of a 2-Pyridone, KRQ-10018, against Mycobacterium tuberculosis In Vitro and In Vivo{triangledown}

Anne J. Lenaerts,* Casey Bitting, Lisa Woolhiser, Veronica Gruppo, Karen S. Marietta, Christine M. Johnson, and Ian M. Orme

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 9 July 2007/ Returned for modification 1 October 2007/ Accepted 30 January 2008

A novel subclass of quinolones, 2-pyridones, showed potent activity against Mycobacterium tuberculosis, with KRQ-10018 being an early lead. KRQ-10018 showed better activity in vitro against M. tuberculosis versus moxifloxacin. In vivo efficacy of KRQ-10018 at 300 mg/kg of body weight was similar to that of isoniazid at 25 mg/kg, but showed less activity than moxifloxacin at 300 mg/kg.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-3079. Fax: (970) 491-5125. E-mail: lenaerts{at}colostate.edu

{triangledown} Published ahead of print on 11 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1513-1515, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00897-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dharmadhikari, A. S., Nardell, E. A. (2008). What Animal Models Teach Humans about Tuberculosis. Am. J. Respir. Cell Mol. Bio. 39: 503-508 [Abstract] [Full Text]  


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