AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.00897-07v1
52/4/1513    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Lenaerts, A. J.
Right arrow Articles by Orme, I. M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lenaerts, A. J.
Right arrow Articles by Orme, I. M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2008, p. 1513-1515, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00897-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of a 2-Pyridone, KRQ-10018, against Mycobacterium tuberculosis In Vitro and In Vivo{triangledown}

Anne J. Lenaerts,* Casey Bitting, Lisa Woolhiser, Veronica Gruppo, Karen S. Marietta, Christine M. Johnson, and Ian M. Orme

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 9 July 2007/ Returned for modification 1 October 2007/ Accepted 30 January 2008

A novel subclass of quinolones, 2-pyridones, showed potent activity against Mycobacterium tuberculosis, with KRQ-10018 being an early lead. KRQ-10018 showed better activity in vitro against M. tuberculosis versus moxifloxacin. In vivo efficacy of KRQ-10018 at 300 mg/kg of body weight was similar to that of isoniazid at 25 mg/kg, but showed less activity than moxifloxacin at 300 mg/kg.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-3079. Fax: (970) 491-5125. E-mail: lenaerts{at}colostate.edu

{triangledown} Published ahead of print on 11 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1513-1515, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00897-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.