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Antimicrobial Agents and Chemotherapy, April 2008, p. 1516-1518, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01474-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Microdialysis Study of Imipenem Distribution in the Peritoneal Fluid of Rats with Experimental Acute Pancreatitis{triangledown}

Sandrine Lefeuvre,1,2,3 Sandrine Marchand,1,2,3 Claudine Pariat,1,2 Isabelle Lamarche,1,2 and William Couet1,2,3*

Inserm, ERI-23, 40 avenue du Recteur Pineau, Poitiers, France,1 Université de Poitiers, UFR Médecine-Pharmacie, 6 rue de la Milétrie, Poitiers, France,2 CHU Poitiers, 2 rue de la Milétrie, Poitiers, France3

Received 14 November 2007/ Returned for modification 16 December 2007/ Accepted 4 January 2008

Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.

* Corresponding author. Mailing address: INSERM, ERI-23, Pôle Biologie Santé, 40 Avenue du Recteur, 86000 Poitiers, France. Phone: (33) 5 49 45 43 79. Fax: (33) 5 49 45 43 78. E-mail: william.couet{at}univ-poitiers.fr

{triangledown} Published ahead of print on 14 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1516-1518, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01474-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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