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Antimicrobial Agents and Chemotherapy, April 2008, p. 1519-1521, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01241-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Anti-BK Virus Activity of Nucleoside Analogs{triangledown}

Parmjeet Randhawa,1* Jiri Zemlicka,2 Andreas Sauerbrei,3 Chris Meier,4 Karl Y. Hostetler,5 James R. Beadle,5 Noush Afarin Farasati,1 Yuchen Huang,1 and Matthews Bradley5,6

Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,1 Developmental Therapeutics Program, Barbara Ann Karmanos Institute,2 Wayne State University School of Medicine, Detroit, Michigan 48201-1379; Institute of Virology and Antiviral Chemotherapy, University of Jena, Jena, Germany,3 Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany,4 Department of Medicine, University of California, San Diego, La Jolla, California 92093-0676,5 Luitpold Pharmaceuticals, Annapolis, Maryland6

Received 21 September 2007/ Returned for modification 30 November 2007/ Accepted 20 December 2007

Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.

* Corresponding author. Mailing address: Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room E737, UPMC-Montefiore Hospital, 3459 Fifth Ave., Pittsburgh, PA 15213. Phone: (412) 647-7646. Fax: (412) 647-5237. E-mail: randhawapa{at}upmc.edu

{triangledown} Published ahead of print on 19 February 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1519-1521, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01241-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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