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Antimicrobial Agents and Chemotherapy, April 2008, p. 1525-1528, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01485-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Induction of L1 and L2 β-Lactamase Production in Stenotrophomonas maltophilia Is Dependent on an AmpR-Type Regulator{triangledown}

Aki Okazaki and Matthew B. Avison*

Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular & Molecular Medicine, University of Bristol, Bristol, United Kingdom

Received 15 November 2007/ Returned for modification 6 January 2008/ Accepted 12 January 2008

A divergently oriented ampR has been located upstream of blaL2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 β-lactamase induction in response to β-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.

* Corresponding author. Mailing address: Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom. Phone: 44 (0)1173312036. Fax: 44 (0)1179287897. E-mail: matthewb.avison{at}bris.ac.uk

{triangledown} Published ahead of print on 22 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1525-1528, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01485-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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