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Antimicrobial Agents and Chemotherapy, April 2008, p. 1529-1532, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01097-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Interactions of Micafungin with Amphotericin B against Clinical Isolates of Candida spp.

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain,¹ Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Spain,² Departamento de Microbiología, Asesoría Científica y de Investigación Aplicada, Barcelona, Spain³

Received 21 August 2007/ Returned for modification 10 November 2007/ Accepted 20 January 2008

The in vitro activity of amphotericin B in combination with micafungin was evaluated against 115 isolates representing seven species of Candida. Overall, the percentages of synergistic interactions were 50% and 20% when the MIC-2 (lowest drug concentration to cause a prominent reduction in growth) and MIC-0 (lowest drug concentration to cause 100% growth inhibition) end point criteria, respectively, were used. Antagonism was not observed. Some of the interactions were confirmed by time-kill assays.

Published ahead of print on 28 January 2008.