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Antimicrobial Agents and Chemotherapy, April 2008, p. 1533-1537, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01254-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype{triangledown}

Brian T. Tsuji,1,2* Christof von Eiff,3 Pamela A. Kelchlin,1 Alan Forrest,1 and Patrick F. Smith1,2,{dagger}

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences—Buffalo, and The New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260,1 Departments of Pharmacy and Medicine, Roswell Park Cancer Institute, Buffalo, New York 14260,2 Institute of Medical Microbiology, University of Münster, Münster, Germany3

Received 25 September 2007/ Returned for modification 30 October 2007/ Accepted 23 January 2008

The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

* Corresponding author. Mailing address: School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 331 Cooke Hall, Buffalo, NY 14260. Phone: (716) 881-7543. Fax: (716) 645-2886. E-mail: btsuji{at}buffalo.edu

{triangledown} Published ahead of print on 19 February 2008.

{dagger} Present address: Roche Pharmaceuticals, Nutley, NJ.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1533-1537, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01254-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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