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Antimicrobial Agents and Chemotherapy, April 2008, p. 1538-1541, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00140-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effect of 14-Membered-Ring Macrolides on Production of Interleukin-8 Mediated by Protease-Activated Receptor 2 in Human Keratinocytes{triangledown}

Tatsuya Tsuda,1,3,{dagger} Chika Ishikawa,1,{dagger} Hiroe Konishi,1 Yoshiaki Hayashi,1 Noboru Nakagawa,1 Masato Matsuki,1 Hitoshi Mizutani,3 and Kiyofumi Yamanishi1,2*

Department of Dermatology,1 High-Tech Research Institute, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan,2 Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan3

Received 31 January 2007/ Returned for modification 10 April 2007/ Accepted 10 January 2008

The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1β were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Those macrolides may attenuate the protease-activated receptor 2-interleukin-8 axis and thereby modulate proinflammatory responses in the skin.

* Corresponding author. Mailing address: Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan. Phone: 81-798-45-6653. Fax: 81-798-45-6651. E-mail: kyamanis{at}hyo-med.ac.jp

{triangledown} Published ahead of print on 22 January 2008.

{dagger} T.T. and C.I. contributed equally to this work.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1538-1541, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.00140-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ishikawa, C., Tsuda, T., Konishi, H., Nakagawa, N., Yamanishi, K. (2009). Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes. Antimicrob. Agents Chemother. 53: 1760-1765 [Abstract] [Full Text]  


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