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Antimicrobial Agents and Chemotherapy, April 2008, p. 1545-1548, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01284-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors{triangledown}

Delphine Desbois,1 Bénédicte Roquebert,1 Gilles Peytavin,2 Florence Damond,1 Gilles Collin,1 Antoine Bénard,5 Pauline Campa,4 Sophie Matheron,3 Geneviève Chêne,5 Françoise Brun-Vézinet,1 Diane Descamps,1* for the French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2)

Laboratoire de Virologie, Service de Microbiologie, Hôpital Bichat-Claude Bernard, Paris, France,1 Laboratoire de Toxicologie, Service de Pharmacie, Hôpital Bichat-Claude Bernard, Paris, France,2 Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Paris, France,3 Service de Maladies Infectieuses et Tropicales, Hôpital Saint-Antoine, Paris, France,4 ISPED, Université Victor Segalen Bordeaux 2, INSERM U593, Bordeaux, France5

Received 4 October 2007/ Returned for modification 19 November 2007/ Accepted 14 January 2008

We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, lopinavir, and darunavir are potent against wild-type HIV-2 isolates and should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors are less active against HIV-2 than against HIV-1.

* Corresponding author. Mailing address: Laboratoire de Virologie, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France. Phone: 33 1 40 25 61 54. Fax: 33 1 40 25 67 69. E-mail: diane.descamps{at}bch.aphp.fr

{triangledown} Published ahead of print on 28 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1545-1548, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01284-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ntemgwa, M. L., Toni, T. d., Brenner, B. G., Camacho, R. J., Wainberg, M. A. (2009). Antiretroviral Drug Resistance in Human Immunodeficiency Virus Type 2. Antimicrob. Agents Chemother. 53: 3611-3619 [Full Text]  
  • Descamps, D., Lambert-Niclot, S., Marcelin, A.-G., Peytavin, G., Roquebert, B., Katlama, C., Yeni, P., Felices, M., Calvez, V., Brun-Vezinet, F. (2009). Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients. J Antimicrob Chemother 63: 585-592 [Abstract] [Full Text]  
  • Roquebert, B., Damond, F., Collin, G., Matheron, S., Peytavin, G., Benard, A., Campa, P., Chene, G., Brun-Vezinet, F., Descamps, D., on behalf of the French ANRS HIV-2 Cohort (ANRS CO, (2008). HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. J Antimicrob Chemother 62: 914-920 [Abstract] [Full Text]  


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