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Antimicrobial Agents and Chemotherapy, April 2008, p. 1556-1558, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01458-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Combination Echinocandin-Polyene Treatment of Murine Mucormycosis{triangledown}

Ashraf S. Ibrahim,1,2* Teclegiorgis Gebremariam,1 Yue Fu,1,2 John E. Edwards Jr.,1,2 and Brad Spellberg1,2

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California,1 David Geffen School of Medicine at UCLA, Los Angeles, California2

Received 10 November 2007/ Returned for modification 9 January 2008/ Accepted 14 January 2008

We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.

* Corresponding author. Mailing address: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson St., RB2, Torrance, CA 90502. Phone: (310) 222-6424. Fax: (310) 782-2016. E-mail: ibrahim{at}labiomed.org

{triangledown} Published ahead of print on 22 January 2008.

Antimicrobial Agents and Chemotherapy, April 2008, p. 1556-1558, Vol. 52, No. 4
0066-4804/08/$08.00+0     doi:10.1128/AAC.01458-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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