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Antimicrobial Agents and Chemotherapy, April 2008, p. 1556-1558, Vol. 52, No. 4
0066-4804/08/$08.00+0 doi:10.1128/AAC.01458-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California,1 David Geffen School of Medicine at UCLA, Los Angeles, California2
Received 10 November 2007/ Returned for modification 9 January 2008/ Accepted 14 January 2008
We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
Published ahead of print on 22 January 2008.
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