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Antimicrobial Agents and Chemotherapy, May 2008, p. 1829-1833, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01480-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, against Extracellular and Intracellular Staphylococcus aureus and Its Stable Small-Colony Variant in Human Monocyte-Derived Macrophages and in Broth{triangledown}

Aldona L. Baltch,1,2* William J. Ritz,1,2 Lawrence H. Bopp,1 Phyllis Michelsen,1,2 and Raymond P. Smith1,2

Infectious Disease Research Laboratory, Stratton VA Medical Center,1 Albany Medical College, Albany, New York2

Received 14 November 2007/ Returned for modification 4 December 2007/ Accepted 25 February 2008

We investigated the antistaphylococcal activities of daptomycin, gentamicin, and rifampin against two Staphylococcus aureus strains and their stable small-colony variants, singly and in combination, in human monocyte-derived macrophages and in broth. Intracellularly, the three-drug combination and two-drug combinations with rifampin were most effective. Extracellularly, daptomycin, daptomycin plus gentamicin, gentamicin plus rifampin, and the three-drug combination had similar activities.

* Corresponding author. Mailing address: Infectious Disease Research Laboratory, Stratton VA Medical Center, Albany, NY 12208. Phone: (518) 626-6416. Fax: (518) 626-6564. E-mail: Aldona.Baltch{at}med.va.gov

{triangledown} Published ahead of print on 10 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1829-1833, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01480-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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