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A Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes

Department of Medicine, Division of Dermatology, University of California, San Diego,¹ VA San Diego Healthcare Center, San Diego,² Moores Cancer Center, University of California, San Diego,³ Department of Chemistry and Biochemistry, University of California, San Diego, San Diego,⁴ Applied Biosystems, Foster City, California⁵

Received 18 October 2007/ Returned for modification 3 January 2008/ Accepted 11 February 2008

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

Published ahead of print on 19 February 2008.