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Antimicrobial Agents and Chemotherapy, May 2008, p. 1834-1836, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01347-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

A Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes{triangledown}

Chun-Ming Huang,1,2,3* Justin W. Torpey,4 Yu-Tseung Liu,3 Yun-Ru Chen,1,2 Katherine E. Williams,5 Elizabeth A. Komives,4 and Richard L. Gallo1,2

Department of Medicine, Division of Dermatology, University of California, San Diego,1 VA San Diego Healthcare Center, San Diego,2 Moores Cancer Center, University of California, San Diego,3 Department of Chemistry and Biochemistry, University of California, San Diego, San Diego,4 Applied Biosystems, Foster City, California5

Received 18 October 2007/ Returned for modification 3 January 2008/ Accepted 11 February 2008

Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

* Corresponding author. Mailing address: Division of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm. 3217A, 3350 La Jolla Village Drive, San Diego, CA. Phone: (858) 552-8585, ext. 3708. Fax: (858) 642-1435. E-mail: chunming{at}ucsd.edu

{triangledown} Published ahead of print on 19 February 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1834-1836, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01347-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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