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Antimicrobial Agents and Chemotherapy, May 2008, p. 1840-1842, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01478-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Differential Effects of Quinoline Antimalarials on Endocytosis in Plasmodium falciparum{triangledown}

Lindi Roberts,1 Timothy J. Egan,2 Keith A. Joiner,3 and Heinrich C. Hoppe1,4*

Division of Pharmacology, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa,1 Department of Chemistry, University of Cape Town, Cape Town, South Africa,2 Departments of Medicine and Cell Biology and Anatomy, University of Arizona School of Medicine, Tuscon, Arizona,3 Biosciences Division, CSIR, PO Box 395, Pretoria 0001, South Africa4

Received 14 November 2007/ Returned for modification 18 December 2007/ Accepted 26 February 2008

The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.

* Corresponding author. Mailing address: Division of Pharmacology, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa. Phone: 27-12-841 4363. Fax: 27-12-841 3651. E-mail: hhoppe{at}csir.co.za

{triangledown} Published ahead of print on 3 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1840-1842, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01478-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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