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Antimicrobial Agents and Chemotherapy, May 2008, p. 1843-1845, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01477-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Detection of Methyltransferases Conferring High-Level Resistance to Aminoglycosides in Enterobacteriaceae from Europe, North America, and Latin America{triangledown}

Thomas R. Fritsche,1* Mariana Castanheira,1 George H. Miller,2 Ronald N. Jones,1,3 and Eliana S. Armstrong2

JMI Laboratories, North Liberty, Iowa,1 Achaogen, Inc., South San Francisco, California,2 Tufts University School of Medicine, Boston, Massachusetts3

Received 14 November 2007/ Returned for modification 21 December 2007/ Accepted 25 February 2008

The alteration of ribosomal targets by recently described 16S rRNA methyltransferases confers resistance to most aminoglycosides, including arbekacin. Enterobacteriaceae and nonfermentative bacilli acquired through global surveillance programs were screened for the presence of these enzymes on the basis of phenotypes that were resistant to nine tested aminoglycosides. Subsequent molecular studies determined that 20 of 21 (95.2%) methyltransferase-positive isolates consisted of novel species records or geographic occurrences (North America [armA and rmtB], Latin America [rmtD], and Europe [armA]; rmtA, rmtC, and npmA were not detected). The global emergence of high-level aminoglycoside resistance has become a rapidly changing event requiring careful monitoring.

* Corresponding author. Mailing address: JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 655-3371. E-mail: Thomas-fritsche{at}jmilabs.com

{triangledown} Published ahead of print on 17 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1843-1845, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01477-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Folster, J. P., Rickert, R., Barzilay, E. J., Whichard, J. M. (2009). Identification of the Aminoglycoside Resistance Determinants armA and rmtC among Non-Typhi Salmonella Isolates from Humans in the United States. Antimicrob. Agents Chemother. 53: 4563-4564 [Full Text]  
  • Doi, Y., Adams-Haduch, J. M., Paterson, D. L. (2008). Genetic Environment of 16S rRNA Methylase Gene rmtD. Antimicrob. Agents Chemother. 52: 2270-2272 [Abstract] [Full Text]  


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