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Activity of Daptomycin against Listeria monocytogenes Isolates from Cerebrospinal Fluid

Lodewijk Spanjaard^* and Christina M. J. E. Vandenbroucke-Grauls

Netherlands Reference Laboratory for Bacterial Meningitis, Department of Medical Microbiology, and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Received 29 August 2007/ Returned for modification 20 November 2007/ Accepted 13 February 2008

We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC₉₀) was 4.0 mg/liter. For the Etest method, the MIC range was 1.0 to 4.0 and the MIC₉₀ was 4.0 mg/liter. Presently, daptomycin cannot be recommended for the treatment of L. monocytogenes meningitis.

Published ahead of print on 19 February 2008.

Present address: Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.