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*Chlamydia Infections

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Antimicrobial Agents and Chemotherapy, May 2008, p. 1855-1858, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01567-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Efficacy of Benzoxazinorifamycins in a Mouse Model of Chlamydia pneumoniae Lung Infection{triangledown}

Lee Ann Campbell,1 Cho-Chou Kuo,1 Robert J. Suchland,2 and David M. Rothstein3*

Departments of Pathobiology and Epidemiology, University of Washington, Seattle, Washington 98195,1 Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98195,2 ActivBiotics, Inc., 110 Hartwell Avenue, Lexington, Massachusetts 024213

Received 5 December 2007/ Returned for modification 3 January 2008/ Accepted 18 February 2008

The efficacy of rifalazil and other benzoxazinorifamycins was tested in a mouse model of lung infection against Chlamydia pneumoniae. Rifalazil and six related new chemical entities all showed efficacy after one dose per day for 3 days at either 3 or 1 mg/kg of body weight.

* Corresponding author. Present address: EarthGenes Pharmaceuticals, 107 Cedar Street, Lexington, MA 02421. Phone: (339) 223-9365. E-mail: drothstein{at}rcn.com

{triangledown} Published ahead of print on 10 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1855-1858, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01567-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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