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Antimicrobial Agents and Chemotherapy, May 2008, p. 1862-1864, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01208-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Synergy of a Hepatitis C Virus (HCV) NS4A Antagonist in Combination with HCV Protease and Polymerase Inhibitors{triangledown}

David L. Wyles,* Kelly A. Kaihara, and Robert T. Schooley

Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California

Received 12 September 2007/ Returned for modification 1 November 2007/ Accepted 29 February 2008

Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside and nonnucleoside polymerase inhibitors.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Medicine, University of California, 9500 Gilman Drive, MC 0711, La Jolla, CA 92093. Phone: (858) 822-1779. Fax: (858) 822-5362. E-mail: dwyles{at}ucsd.edu

{triangledown} Published ahead of print on 10 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1862-1864, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01208-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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