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Antimicrobial Agents and Chemotherapy, May 2008, p. 1873-1875, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01572-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Susceptibility Testing of Anidulafungin and Voriconazole Alone and in Combination against Conidia and Hyphae of Aspergillus spp. under Hypoxic Conditions{triangledown}

Susanne Perkhofer,* Daniel Jost, Manfred P. Dierich, and Cornelia Lass-Flörl

Medical University of Innsbruck, Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck, Austria

Received 7 December 2007/ Returned for modification 29 December 2007/ Accepted 6 March 2008

MICs and fractional inhibitory concentrations were evaluated for anidulafungin and voriconazole alone and in combination against conidia and hyphae under hypoxic (1% oxygen-5% CO2-94% nitrogen) conditions against 31 Aspergillus isolates. Anidulafungin exhibited excellent activity against conidia and hyphae of Aspergillus spp. The visual reading of the MIC for anidulafungin was optimal under hypoxic conditions.

* Corresponding author. Mailing address: Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. Phone: 43 512 9003 70729. Fax: 43 512 9003 73700. E-mail: Susanne.Perkhofer{at}i-med.ac.at

{triangledown} Published ahead of print on 17 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1873-1875, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01572-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • van de Sande, W. W. J., Mathot, R. A. A., ten Kate, M. T., van Vianen, W., Tavakol, M., Rijnders, B. J. A., Bakker-Woudenberg, I. A. J. M. (2009). Combination Therapy of Advanced Invasive Pulmonary Aspergillosis in Transiently Neutropenic Rats Using Human Pharmacokinetic Equivalent Doses of Voriconazole and Anidulafungin. Antimicrob. Agents Chemother. 53: 2005-2013 [Abstract] [Full Text]  


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