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Antimicrobial Agents and Chemotherapy, May 2008, p. 1876-1879, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01308-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3{triangledown}

Kerstin Hinrichsen,1 Rainer Podschun,2 Sabine Schubert,2 Jens M. Schröder,1 Jürgen Harder,1,{dagger}* and Ehrhardt Proksch1,{dagger}

Department of Dermatology,1 Institute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany2

Received 10 October 2007/ Returned for modification 6 November 2007/ Accepted 27 February 2008

Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.

* Corresponding author. Mailing address: University Hospital Schleswig-Holstein, Department of Dermatology, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany. Phone: 49 431 5971598. Fax: 49 431 5975243. E-mail: jharder{at}dermatology.uni-kiel.de

{triangledown} Published ahead of print on 10 March 2008.

{dagger} J.H. and E.P. share senior authorship of this article.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1876-1879, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01308-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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