AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
AAC.01308-07v1
52/5/1876    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Hinrichsen, K.
Right arrow Articles by Proksch, E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hinrichsen, K.
Right arrow Articles by Proksch, E.
Antimicrobial Agents and Chemotherapy, May 2008, p. 1876-1879, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01308-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3{triangledown}

Kerstin Hinrichsen,1 Rainer Podschun,2 Sabine Schubert,2 Jens M. Schröder,1 Jürgen Harder,1,{dagger}* and Ehrhardt Proksch1,{dagger}

Department of Dermatology,1 Institute for Infection Medicine, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany2

Received 10 October 2007/ Returned for modification 6 November 2007/ Accepted 27 February 2008

Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.

* Corresponding author. Mailing address: University Hospital Schleswig-Holstein, Department of Dermatology, Campus Kiel, Schittenhelmstr. 7, 24105 Kiel, Germany. Phone: 49 431 5971598. Fax: 49 431 5975243. E-mail: jharder{at}dermatology.uni-kiel.de

{triangledown} Published ahead of print on 10 March 2008.

{dagger} J.H. and E.P. share senior authorship of this article.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1876-1879, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01308-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.