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Antimicrobial Agents and Chemotherapy, May 2008, p. 1880-1883, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.00936-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparison of the Efficacies of Oral β-Lactams in Selection of Haemophilus influenzae Transformants with Mutated ftsI Genes{triangledown}

Sho Takahata,* Yoshihisa Kato, Yumiko Sanbongi, Kazunori Maebashi, and Takashi Ida

Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Received 20 July 2007/ Returned for modification 14 October 2007/ Accepted 5 March 2008

Horizontal transfer of the mutated ftsI gene from β-lactamase-nonproducing ampicillin-resistant (BLNAR) Haemophilus influenzae to a susceptible strain was examined in vitro under selection with nine oral β-lactams (ampicillin, amoxicillin, cefprozil, cefuroxime, cefpodoxime, cefdinir, cefcapene, cefditoren, and tebipenem). Compared to the penicillins and the carbapenem, the cephalosporins showed a wide selection window for the genetic transfer.

* Corresponding author. Mailing address: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. Phone: 81-45-545-3139. Fax: 81-45-541-1768. E-mail: sho_takahata{at}meiji.co.jp

{triangledown} Published ahead of print on 17 March 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1880-1883, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.00936-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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