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Antimicrobial Agents and Chemotherapy, May 2008, p. 1884-1887, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01473-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some Candida Species{triangledown}

Rawya S. Al-Dhaheri and L. Julia Douglas*

Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom

Received 14 November 2007/ Returned for modification 13 January 2008/ Accepted 5 February 2008

Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential or stationary phase) contained persister cells. However, persisters were found in biofilms of one of two strains of Candida albicans tested and in biofilms of Candida krusei and Candida parapsilosis, but not in biofilms of Candida glabrata or Candida tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms.

* Corresponding author. Mailing address: Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Phone: 44 141 330 5842. Fax: 44 141 330 4600. E-mail: J.Douglas{at}bio.gla.ac.uk

{triangledown} Published ahead of print on 19 February 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1884-1887, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01473-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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