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Antimicrobial Agents and Chemotherapy, May 2008, p. 1891-1893, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01321-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Pharmacokinetic Evaluation of Single-Dose Intravenous Daptomycin in Patients with Thermal Burn Injury{triangledown}

John F. Mohr III,1* Luis Ostrosky-Zeichner,1 David J. Wainright,2 Donald H. Parks,2 Timothy C. Hollenbeck,2 and Charles D. Ericsson1

Department of Internal Medicine, Division of Infectious Diseases,1 Department of Surgery, Division of Plastic Surgery, University of Texas Health Science Center, Houston, Texas2

Received 12 October 2007/ Returned for modification 11 November 2007/ Accepted 17 February 2008

Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 2.112, Houston, Texas 77030. Phone: (713) 500-6742. Fax: (713) 500-5495. E-mail: john.mohr{at}uth.tmc.edu

{triangledown} Published ahead of print on 25 February 2008.

Antimicrobial Agents and Chemotherapy, May 2008, p. 1891-1893, Vol. 52, No. 5
0066-4804/08/$08.00+0     doi:10.1128/AAC.01321-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lovering, A. M., Le Floch, R., Hovsepian, L., Stephanazzi, J., Bret, P., Birraux, G., Vinsonneau, C. (2009). Pharmacokinetic evaluation of linezolid in patients with major thermal injuries. J Antimicrob Chemother 63: 553-559 [Abstract] [Full Text]  
  • Seaton, R. A. (2008). Daptomycin: rationale and role in the management of skin and soft tissue infections. J Antimicrob Chemother 62: iii15-iii23 [Abstract] [Full Text]  


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