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Antimicrobial Agents and Chemotherapy, June 2008, p. 2009-2013, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01594-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis{triangledown}

G. C. Kedar,* Vickie Brown-Driver, Daniel R. Reyes, Mark T. Hilgers, Mark A. Stidham, Karen Joy Shaw, John Finn, and Robert J. Haselbeck

Trius Therapeutics, Inc., 6310 Nancy Ridge Drive, Suite 105, San Diego, California 92121

Received 10 December 2007/ Returned for modification 7 January 2008/ Accepted 19 March 2008

Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug.

* Corresponding author. Mailing address: Trius Therapeutics, Inc., 6310 Nancy Ridge Drive, Suite 105, San Diego, CA 92121. Phone: (858) 452-0370, x224. Fax: (858) 452-0412. E-mail: kgc{at}triusrx.com

{triangledown} Published ahead of print on 31 March 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2009-2013, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01594-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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